Synthesis of Acetaminophen Essay - 1231 Words

Synthesis of Acetaminophen Lab Report Bijal Patel, 20467049 Partner: Poojan Parikh T.A.’s: Long Pu CHEM 123L, Section: 006, Rm: ESC 149 Tuesday February 4, 2013, 2:30pm-5:20pm Experiment Done: Tuesday January 22, 2013 Introduction Acetaminophen was first introduced in 1955 (Richman, 2004). It is an over-the-counter drug that relieves pain and reduced fevers. Acetaminophen is considered an alternate to aspirin since it does not irritate the stomach (Richman, 2004). It also has very low toxicity is it is used properly. Acetaminophen is cheap and easily obtainable from any pharmacy. Acetaminophen is created when the amine group of p-aminophenol is acetylated by acetic anhydride. This creates an amide functional group and the†¦show more content†¦There were very few, if any, errors made during this lab. Questions 1. a) If 20 mL of water were added for every 1g of crude product then crystallization would occur in less quantity or not occur at all. As the solution is dissolved, heated, and later cooled, the impurities of the solution remain in the solution. As more solvent is added, more of the product will remain in the solution rather than crystallizing; hence, a much lower yield would be obtained. b) If 5mL of water were added for every 1g of crude product then one of two things would happen; the solid would not dissolve or the impurities would still be present within the product. The solvent is used to dissolve all the impurities of the crude product and if less solvent is available, the impurities would remain within the product. c) If room temperature solvent was used rather than cold solvent then more of the product will remain in the solution. As temperature increases, solubility also increases in most cases, which would keep some of the product dissolved resulting in a lower yield. 2. a) An organic compound is any compound that contains carbon, generally, are large chains of carbon that are covalently bonded. They can be gaseous, liquid or a solid (Seager; Slabaug, 2004). b) An amine is an organic compound/functional group that is derived by replacing one or more of its hydrogen atoms in ammoniaShow MoreRelatedThe Melting Point Analysis of Crude and Recrystallized Acetaminophen Synthesized from P-Aminophenol and Acetic Anhydride1092 Words   |  5 Pagesvial attached to an air condenser to synthesize crude acetaminophen, resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken, and found to be 165.9 - 170.9 °C and 168.2 - 171.5 °C, respectively. The literature melting point of acetaminophen is 169.5 – 171.0 °C, indicating that our final product wasRead MorePharmacologic Management Of SCD Pain Case Study753 Words   |  4 Pagespharmacotherapy of SCD pain. Non-opioid analgesics include acetaminophen, nonsteroidal anti-inflammatory drug s (NSAIDs) and COX-2 inhibitors. Acetaminophen Acetaminophen has analgesic and antipyretic effects but it does not reduce inflammation (Botting, 2000). The daily total dose should not exceed 4g, since it has been associated with hepatotoxicity (Hu et al., 2017, Kelava and Cavar, 2014). Although the therapeutic doses of acetaminophen are not associated with hepatotoxicity, in patients with liverRead MoreLack Of Crystals Forming During The Ice Bath Essay1580 Words   |  7 Pagesproduct for the filter to the watch glass. A small error was also made by not weighing the watch glass before the Acetaminophen had been transferred to it for drying. This meant that one friend the Acetaminophen had to then be transferred again into a weighed watch glass, this is another example of where product could have been lost thus affecting the yield percentage. The yielded Acetaminophen had a melting point of 174 oC this was slightly outside the melting point range of 169 oC - 171 oC thereforeRead MoreThe Drug Development And Approval Process1184 Words   |  5 Pagesphases and data on how the drug is manufactured (Frank Hargreaves, 2003; Lipsky Sharp, 2001; Krishna, Herman, Wagner, 2008). Acetaminophen, also known as paracetamol and N-acetyl-p-aminophenol in chemical nomenclature (APAP), is a widely used analgesic and antipyretic (Patten et al., 1993). It is thought to function as an inhibitor of prostaglandin synthesis, which may be a mediator in central nervous system pain and fever by raising the pain threshold, impacting temperature regulation, therebyRead MoreA Short Note On Opioid And Opioid Analgesics1182 Words   |  5 Pagescommonly used pharmacological medications (Nadine Matthie, 2015). Generic name: acetaminophen, trade name: Tylenol. Acetaminophen is an antipyretic, and nonopioid analgesic used as pain reliever. It suppresses the synthesis of prostaglandins which controls the pain and fever receptors primarily in CNS (Vallerand Deglin, 2017). Common side effects are, increase agitation in children, hypertension, hypotension. Acetaminophen is known as â€Å"safest over-the-counter drug† though, it requires close monitorRead MoreThe Drug Developme nt And Approval Process1169 Words   |  5 Pagesphases and data on how the drug is manufactured (Frank Hargreaves, 2003; Lipsky Sharp, 2001; Krishna, Herman, Wagner, 2008). Acetaminophen, also known as paracetamol and N-acetyl-p-aminophenol in chemical nomenclature (APAP), is a widely used analgesic and antipyretic (Patten et al., 1993). It is thought to function as an inhibitor of prostaglandin synthesis, which may be a mediator in central nervous system pain and fever by raising the pain threshold, impacting temperature regulation, therebyRead MoreThe Drug Development And Approval Process1179 Words   |  5 Pagesphases and data on how the drug is manufactured (Frank Hargreaves, 2003; Lipsky Sharp, 2001; Krishna, Herman, Wagner, 2008). Acetaminophen, also known as paracetamol and N-acetyl-p-aminophenol in chemical nomenclature (APAP), is a widely used analgesic and antipyretic (Patten et al., 1993). It is thought to function as an inhibitor of prostaglandin synthesis, which may be a mediator in central nervous system pain and fever by raising the pain threshold, impacting temperature regulation, therebyRead MoreThe Drug Development And Approval Process1210 Words   |  5 Pagesphases and data on how the drug is manufactured (Frank Hargreaves, 2003; Lipsky Sharp, 2001; Krishna, Herman, Wagner, 2008). Acetaminophen, also known as paracetamol and N-acetyl-p-aminophenol in chemical nomenclature (APAP), is a widely used analgesic and antipyretic (Patten et al., 1993). It is thought to function as an inhibitor of prostaglandin synthesis, which may be a mediator in central nervous system pain and fever by raising the pain threshold, impacting temperature regulation, therebyRead MoreSynthesis Of P Hydroxy Acetanilide1067 Words   |  5 PagesSynthesis of P-Hydroxy Acetanilide (Paracetamol) Kirstie Leckie B00266969 Abstract In this experiment the aim was to obtain a pure sample of paracetamol by reduction of p-aminophenol with acetic anhydride. The process carried out to obtain the paracetamol included mixing p-aminophenol, the starting product, with acetic anhydride suspended in distilled water until a precipitate formed (the product). The product was filtered, dried and recrystallized to purify. 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